Comparative medicine

Comparative medicine represents a revolutionary advance in medical research, with companion animals emerging as a valuable predictive model for human disease. Conventional in-vivo models have obvious translational limitations, underlining the need to explore innovative approaches to understanding and treating medical conditions.
Dogs and cats, as individuals subject to natural diseases, share many clinical, physiological and genetic characteristics with humans. This similarity offers a unique opportunity to study complex pathologies in a natural context, broadening our understanding of the mechanisms underlying.

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How companion animals can contribute to human health ?

Ethical approach in comparative medicine

The advanced veterinary care for pet animals provides an established infrastructure for clinical trials in pet animals. Pets included in clinical trials are treated as real patients with safe new diagnostic or therapeutic tools under development for Human. Veterinarians and pet owners are encouraged to participate in comparative medicine studies by providing biological materials and clinical data because ultimately pet-patients and their owners will derive great benefit from current research. The clinical trials allow pets to access to innovative diagnostic approach, and safe therapeutic solutions under development for humans. The proposal is a pioneering research program strongly involved in the One Health – One Medicine Concept for both Humans and Pets.

Establishing a pharmacological continuum :

The pharmacological similarities between companion animals and humans provide an ideal continuum for studying drug responses. Understanding comparative pharmacology allows us to anticipate the effects of drugs in humans, facilitating the development of safer and more effective therapies.

Shared pharmacokinetics and toxicology :

Pharmacokinetic and toxicology studies in companion animals provide crucial information on the distribution, metabolism and elimination of drugs. This in-depth knowledge enables treatment protocols to be optimised, minimising the risks to human patients in clinical trials.

Reliability of clinical trials :

By using animal models of natural diseases, comparative medicine offers a more realistic platform for clinical research. Results obtained in companion animals can be more reliably extrapolated to the human population, thereby strengthening the validity of clinical trials.

gray short coated dog lying on floor

Revolutionising Medical Research

By adopting comparative medicine, we are paving the way for significant medical discoveries and advances. Pets are not only our faithful companions, they also become invaluable partners in the quest to understand and treat human diseases.

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